In the remote South African bush, Ralph and Robyn have captured the villainous Josef Gerhard and made him their prisoner. After his monstrous predasaurs unleashed a deadly virus on the world, he deserves to pay. It's finally time to leave the wilderness and head to the city, so they can expose Gerhard's crimes and deliver a vaccine that will save millions. But predators stalk the streets there too, and this time they've got a killer sting... Will Ralph and Robyn be able to get the cure out in time? And can they avoid Gerhard's savage creations long enough to survive?